Endocrine Abstracts

The hGH gene is expressed in epithelial cells of the normal human mammary gland. Increased epithelial expression of the hGH gene is associated with the acquisition of pathological proliferation, and the highest level of hGH gene expression is observed in metastatic mammary carcinoma cells. Autocrine hGH production in human mammary carcinoma cells results in increased cell proliferation and survival associated with alterations in morphology. We have further demonstrated that au...